OBP fused with cell-penetrating peptides promotes liposomal transduction
نویسندگان
چکیده
منابع مشابه
Protein transduction in human cells is enhanced by cell-penetrating peptides fused with an endosomolytic HA2 sequence.
Endocytosis has been proposed as one of the primary mechanisms for cellular entry of cell-penetrating peptides (CPPs) and their cargoes. However, a major limitation of endocytic pathway is entrapment of the CPP-cargo in intracellular vesicles from which the cargo must escape into the cytoplasm to exert its biological activity. Here we demonstrate that a CPP tagged with an endosomolytic fusion p...
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Cell membranes are permeable only for small hydrophobic compounds. While in-vitro transfection studies can be performed with viral factors, electroporation, magneto-fection or application of lipid detergents the internalization of cargos for medically relevant purposes requires more gentle methods such as use of nano-particles or cell-penetrating peptides (CPPs). Especially the formation and in...
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ژورنال
عنوان ژورنال: Colloids and Surfaces B: Biointerfaces
سال: 2018
ISSN: 0927-7765
DOI: 10.1016/j.colsurfb.2017.11.026